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Learn More. Background: Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease COPD but the relationship between proximal airways inflammation and both dynamic collapse of the peripheral airways and HRCT determined emphysema severity remains unknown.

Methods: Sixty five subjects 11 healthy smokers, 44 smokers with stage 0—IV COPD, and 10 healthy non-smokers were assessed using lung function testing and HRCT scanning to quantify emphysema and peripheral airway dysfunction and sputum induction to measure airway inflammation. These references are in PubMed. This may not be the complete list of references from this article. National Center for Biotechnology Information , U.

Journal List Thorax v. Author information Copyright and License information Disclaimer. Copyright notice. This article has been cited by other articles in PMC. Abstract Background: Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease COPD but the relationship between proximal airways inflammation and both dynamic collapse of the peripheral airways and HRCT determined emphysema severity remains unknown.

The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med. Lung disease in long-term cigarette smokers with and without chronic air-flow obstruction.

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Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alphaantitrypsin deficiency and the role of leukotriene B-4 and interleukin Thorax ; Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis.

Hansell DM. Small airways disease: detection and insight with computed tomography. Eur Respir J ; COPD exacerbations. Thorax Nelson Award for being the top student in advanced advocacy courses.

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